What is the recommended storage temperature range for most vaccines in deployed settings?

• A. -20°C to -10°C
• B. 0°C to 2°C
• C. Between 2°C and 8°C
• D. 15°C to 25°C

Answer: (C)

Maintaining vaccine potency requires keeping vaccines in a controlled cold chain, and for the majority of vaccines used in deployed settings that means refrigeration at 2°C to 8°C. This range is chosen because it preserves the stability of most vaccine antigens and live components during storage and transport, avoiding degradation or loss of efficacy that can occur with higher or lower temperatures. Storing at room temperature (15°C to 25°C) risks rapid potency loss, while freezing (-20°C or colder) can damage many vaccines not formulated for freezing. While some vaccines may tolerate brief excursions or have specific storage needs, 2°C to 8°C remains the standard, best-evidence range for most vaccines in the field.